Abstract The seroprevalence, clinical outcomes and lesions of contagious caprine pleuropneumonia (CCPP) in Beetal goats were recorded during an epidemic. The overall seroprevalence of CCPP was 32.50%. Confirmation of the presence of Mycoplasma mycoides in serum was performed using the counterimmunoelectrophoresis (CIE) technique. The highest number of CIE positive cases was recorded in older goats (51.72%) compared to young ones. Nasal swabs were collected from 39 goats that showed respiratory signs and tested positive for mycoplasma. The most consistent clinical findings were mild to severe cough, purulent nasal discharge, emaciation, dyssponia, increased respiratory rate, and pyrexia. Mortality due to CCPP was 9.17%. Lung consolidation showed the highest frequency (100%) followed by alveolar exudation (90.90%) and pleural adhesion (72.72%). Among microscopic lesions, peribronchiolar septal fibrosis showed the highest frequency (81.81%) followed by fibrous pleurisy (63.63%) and peribronchiolar mononuclear cell sheathing (54.54%) in the lungs. From these results it can be concluded that contagious caprine pleuropneumonia in subtropical conditions has a large prevalence in Beetal goats and leads to significant mortality. Keywords: Beetal goat. Pakistan. CCPP. Seroprevalence. PathologyIntroductionCurrently, there are 58.3 million goats in Pakistan and their population is increasing at a rate of more than 3% annually (Afzal, 2010). Pakistan is the third largest goat producing country in the world after China and India. Goat farming in Pakistan is threatened by the prevalence of many infectious and non-infectious diseases. Among infectious diseases, contagious caprine pleuropneumonia represents a serious threat to the goat population... half of the article ......us pleuropneumonia in the acute phase has also been observed in sheep (Momani et al. 2006). Similar lesions have also been reported in animals affected by CCPP that had experienced chronic pleuropneumonia or chronic pleurisy for a longer duration (Gelagay et al. 2007). Histopathologically, the lung tissue showed accumulation of mucopurulent to fibrinopurulent exudates in the aveoli, peribronchiolar septal fibrosis, dilated hyperplastic bronchi, alveolar exudates dominated by macrophages and with a variable component of neutrophils, and fibrosis was also observed in the present study. mononuclear peribronchiolar pulmonary disease. Similar histopathological changes with lower intensity have also been reported in sheep and goats (Goncalves et al. 2010). Clinico-pathological findings and seroprevalence of the disease provided evidence for the presence of CCPP in beetle goats in Faisalabad district.